The Role of Obesity in Cancer Survival and Recurrence
Identifieur interne : 003E24 ( Main/Exploration ); précédent : 003E23; suivant : 003E25The Role of Obesity in Cancer Survival and Recurrence
Auteurs : Wendy Demark-Wahnefried [États-Unis] ; Elizabeth A. Platz [États-Unis] ; Jennifer A. Ligibel [États-Unis] ; Cindy K. Blair [États-Unis] ; Kerry S. Courneya [Canada] ; Jeffrey A. Meyerhardt [États-Unis] ; Patricia A. Ganz [États-Unis] ; Cheryl L. Rock [États-Unis] ; Kathryn H. Schmitz [États-Unis] ; Thomas Wadden [États-Unis] ; Errol J. Philip [États-Unis] ; Bruce Wolfe [États-Unis] ; Susan M. Gapstur [États-Unis] ; Rachel Ballard-Barbash [États-Unis] ; Anne Mctiernan [États-Unis] ; Lori Minasian [États-Unis] ; Linda Nebeling [États-Unis] ; Pamela J. GoodwinSource :
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [ 1055-9965 ] ; 2012.
Abstract
Obesity and components of energy imbalance, i.e., excessive energy intake and suboptimal levels of physical activity, are established risk factors for cancer incidence. Accumulating evidence suggests that these factors also may be important after the diagnosis of cancer and influence the course of disease, as well as overall health, well-being, and survival. Lifestyle and medical interventions that effectively modify these factors could potentially be harnessed as a means of cancer control. However, for such interventions to be maximally effective and sustainable, broad sweeping scientific discoveries ranging from molecular and cellular advances, to developments in delivering interventions on both individual and societal levels are needed. This review summarizes key discussion topics that were addressed in a recent Institute of Medicine Workshop entitled, “The Role of Obesity in Cancer Survival and Recurrence”; discussions included: 1) mechanisms associated with obesity and energy balance that influence cancer progression; 2) complexities of studying and interpreting energy balance in relation to cancer recurrence and survival; 3) associations between obesity and cancer risk, recurrence, and mortality; 4) interventions that promote weight loss, increased physical activity, and negative energy balance as a means of cancer control; and 5) future directions.
Url:
DOI: 10.1158/1055-9965.EPI-12-0485
PubMed: 22695735
PubMed Central: 3415558
Affiliations:
- Canada, États-Unis
- Alabama, Californie, Géorgie (États-Unis), Maryland, Massachusetts, Oregon, Pennsylvanie, Washington (État), État de New York
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Le document en format XML
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Platz</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Ligibel, Jennifer A" sort="Ligibel, Jennifer A" uniqKey="Ligibel J" first="Jennifer A." last="Ligibel">Jennifer A. Ligibel</name><affiliation wicri:level="2"><nlm:aff id="A3">Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Dana-Farber Cancer Institute, Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Blair, Cindy K" sort="Blair, Cindy K" uniqKey="Blair C" first="Cindy K." last="Blair">Cindy K. Blair</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alabama</region></placeName><wicri:cityArea>Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham</wicri:cityArea></affiliation></author><author><name sortKey="Courneya, Kerry S" sort="Courneya, Kerry S" uniqKey="Courneya K" first="Kerry S." last="Courneya">Kerry S. 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Philip</name><affiliation wicri:level="2"><nlm:aff id="A9">Dept of Psychiatry & Behavioral Sciences, Memorial Sloan-Kettering Cancer Ctr, New York, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Dept of Psychiatry & Behavioral Sciences, Memorial Sloan-Kettering Cancer Ctr, New York</wicri:cityArea></affiliation></author><author><name sortKey="Wolfe, Bruce" sort="Wolfe, Bruce" uniqKey="Wolfe B" first="Bruce" last="Wolfe">Bruce Wolfe</name><affiliation wicri:level="2"><nlm:aff id="A10">Department of Surgery, Oregon Health and Science University, Portland, OR</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oregon</region></placeName><wicri:cityArea>Department of Surgery, Oregon Health and Science University, Portland</wicri:cityArea></affiliation></author><author><name sortKey="Gapstur, Susan M" sort="Gapstur, Susan M" uniqKey="Gapstur S" first="Susan M." last="Gapstur">Susan M. 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Platz</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Ligibel, Jennifer A" sort="Ligibel, Jennifer A" uniqKey="Ligibel J" first="Jennifer A." last="Ligibel">Jennifer A. Ligibel</name><affiliation wicri:level="2"><nlm:aff id="A3">Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Dana-Farber Cancer Institute, Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Blair, Cindy K" sort="Blair, Cindy K" uniqKey="Blair C" first="Cindy K." last="Blair">Cindy K. Blair</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alabama</region></placeName><wicri:cityArea>Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham</wicri:cityArea></affiliation></author><author><name sortKey="Courneya, Kerry S" sort="Courneya, Kerry S" uniqKey="Courneya K" first="Kerry S." last="Courneya">Kerry S. Courneya</name><affiliation wicri:level="1"><nlm:aff id="A4">Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Faculty of Physical Education and Recreation, University of Alberta, Edmonton</wicri:regionArea><wicri:noRegion>Edmonton</wicri:noRegion></affiliation></author><author><name sortKey="Meyerhardt, Jeffrey A" sort="Meyerhardt, Jeffrey A" uniqKey="Meyerhardt J" first="Jeffrey A." last="Meyerhardt">Jeffrey A. Meyerhardt</name><affiliation wicri:level="2"><nlm:aff id="A3">Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Dana-Farber Cancer Institute, Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A." last="Ganz">Patricia A. Ganz</name><affiliation wicri:level="2"><nlm:aff id="A5">Schools of Medicine and Public Health, University of California–Los Angeles, Los Angeles, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Schools of Medicine and Public Health, University of California–Los Angeles, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Rock, Cheryl L" sort="Rock, Cheryl L" uniqKey="Rock C" first="Cheryl L." last="Rock">Cheryl L. Rock</name><affiliation wicri:level="2"><nlm:aff id="A6">Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Family and Preventive Medicine, University of California, San Diego, La Jolla</wicri:cityArea></affiliation></author><author><name sortKey="Schmitz, Kathryn H" sort="Schmitz, Kathryn H" uniqKey="Schmitz K" first="Kathryn H." last="Schmitz">Kathryn H. Schmitz</name><affiliation wicri:level="2"><nlm:aff id="A7">Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Wadden, Thomas" sort="Wadden, Thomas" uniqKey="Wadden T" first="Thomas" last="Wadden">Thomas Wadden</name><affiliation wicri:level="2"><nlm:aff id="A8">Center for Weight and Eating Disorders, University of Pennsylvania, Philadelphia, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Center for Weight and Eating Disorders, University of Pennsylvania, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Philip, Errol J" sort="Philip, Errol J" uniqKey="Philip E" first="Errol J." last="Philip">Errol J. Philip</name><affiliation wicri:level="2"><nlm:aff id="A9">Dept of Psychiatry & Behavioral Sciences, Memorial Sloan-Kettering Cancer Ctr, New York, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Dept of Psychiatry & Behavioral Sciences, Memorial Sloan-Kettering Cancer Ctr, New York</wicri:cityArea></affiliation></author><author><name sortKey="Wolfe, Bruce" sort="Wolfe, Bruce" uniqKey="Wolfe B" first="Bruce" last="Wolfe">Bruce Wolfe</name><affiliation wicri:level="2"><nlm:aff id="A10">Department of Surgery, Oregon Health and Science University, Portland, OR</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oregon</region></placeName><wicri:cityArea>Department of Surgery, Oregon Health and Science University, Portland</wicri:cityArea></affiliation></author><author><name sortKey="Gapstur, Susan M" sort="Gapstur, Susan M" uniqKey="Gapstur S" first="Susan M." last="Gapstur">Susan M. Gapstur</name><affiliation wicri:level="2"><nlm:aff id="A11">Epidemiology Research Program, American Cancer Society, Atlanta, GA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Epidemiology Research Program, American Cancer Society, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Ballard Barbash, Rachel" sort="Ballard Barbash, Rachel" uniqKey="Ballard Barbash R" first="Rachel" last="Ballard-Barbash">Rachel Ballard-Barbash</name><affiliation wicri:level="2"><nlm:aff id="A12">Applied Research Program, National Cancer Institute (NCI), Bethesda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Applied Research Program, National Cancer Institute (NCI), Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Mctiernan, Anne" sort="Mctiernan, Anne" uniqKey="Mctiernan A" first="Anne" last="Mctiernan">Anne Mctiernan</name><affiliation wicri:level="2"><nlm:aff id="A13">Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Minasian, Lori" sort="Minasian, Lori" uniqKey="Minasian L" first="Lori" last="Minasian">Lori Minasian</name><affiliation wicri:level="2"><nlm:aff id="A14">Community Oncology and Prevention Trials Research Group, NCI, Bethesda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Community Oncology and Prevention Trials Research Group, NCI, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Nebeling, Linda" sort="Nebeling, Linda" uniqKey="Nebeling L" first="Linda" last="Nebeling">Linda Nebeling</name><affiliation wicri:level="2"><nlm:aff id="A15">Behavioral Research Program, NCI, Bethesda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Behavioral Research Program, NCI, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Goodwin, Pamela J" sort="Goodwin, Pamela J" uniqKey="Goodwin P" first="Pamela J." last="Goodwin">Pamela J. Goodwin</name></author></analytic><series><title level="j">Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</title><idno type="ISSN">1055-9965</idno><idno type="eISSN">1538-7755</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Obesity and components of energy imbalance, i.e., excessive energy intake and suboptimal levels of physical activity, are established risk factors for cancer incidence. Accumulating evidence suggests that these factors also may be important after the diagnosis of cancer and influence the course of disease, as well as overall health, well-being, and survival. Lifestyle and medical interventions that effectively modify these factors could potentially be harnessed as a means of cancer control. However, for such interventions to be maximally effective and sustainable, broad sweeping scientific discoveries ranging from molecular and cellular advances, to developments in delivering interventions on both individual and societal levels are needed. This review summarizes key discussion topics that were addressed in a recent Institute of Medicine Workshop entitled, “The Role of Obesity in Cancer Survival and Recurrence”; discussions included: 1) mechanisms associated with obesity and energy balance that influence cancer progression; 2) complexities of studying and interpreting energy balance in relation to cancer recurrence and survival; 3) associations between obesity and cancer risk, recurrence, and mortality; 4) interventions that promote weight loss, increased physical activity, and negative energy balance as a means of cancer control; and 5) future directions.</p></div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Alabama</li><li>Californie</li><li>Géorgie (États-Unis)</li><li>Maryland</li><li>Massachusetts</li><li>Oregon</li><li>Pennsylvanie</li><li>Washington (État)</li><li>État de New York</li></region></list><tree><noCountry><name sortKey="Goodwin, Pamela J" sort="Goodwin, Pamela J" uniqKey="Goodwin P" first="Pamela J." last="Goodwin">Pamela J. Goodwin</name></noCountry><country name="États-Unis"><region name="Alabama"><name sortKey="Demark Wahnefried, Wendy" sort="Demark Wahnefried, Wendy" uniqKey="Demark Wahnefried W" first="Wendy" last="Demark-Wahnefried">Wendy Demark-Wahnefried</name></region><name sortKey="Ballard Barbash, Rachel" sort="Ballard Barbash, Rachel" uniqKey="Ballard Barbash R" first="Rachel" last="Ballard-Barbash">Rachel Ballard-Barbash</name><name sortKey="Blair, Cindy K" sort="Blair, Cindy K" uniqKey="Blair C" first="Cindy K." last="Blair">Cindy K. Blair</name><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A." last="Ganz">Patricia A. Ganz</name><name sortKey="Gapstur, Susan M" sort="Gapstur, Susan M" uniqKey="Gapstur S" first="Susan M." last="Gapstur">Susan M. Gapstur</name><name sortKey="Ligibel, Jennifer A" sort="Ligibel, Jennifer A" uniqKey="Ligibel J" first="Jennifer A." last="Ligibel">Jennifer A. Ligibel</name><name sortKey="Mctiernan, Anne" sort="Mctiernan, Anne" uniqKey="Mctiernan A" first="Anne" last="Mctiernan">Anne Mctiernan</name><name sortKey="Meyerhardt, Jeffrey A" sort="Meyerhardt, Jeffrey A" uniqKey="Meyerhardt J" first="Jeffrey A." last="Meyerhardt">Jeffrey A. Meyerhardt</name><name sortKey="Minasian, Lori" sort="Minasian, Lori" uniqKey="Minasian L" first="Lori" last="Minasian">Lori Minasian</name><name sortKey="Nebeling, Linda" sort="Nebeling, Linda" uniqKey="Nebeling L" first="Linda" last="Nebeling">Linda Nebeling</name><name sortKey="Philip, Errol J" sort="Philip, Errol J" uniqKey="Philip E" first="Errol J." last="Philip">Errol J. Philip</name><name sortKey="Platz, Elizabeth A" sort="Platz, Elizabeth A" uniqKey="Platz E" first="Elizabeth A." last="Platz">Elizabeth A. Platz</name><name sortKey="Rock, Cheryl L" sort="Rock, Cheryl L" uniqKey="Rock C" first="Cheryl L." last="Rock">Cheryl L. Rock</name><name sortKey="Schmitz, Kathryn H" sort="Schmitz, Kathryn H" uniqKey="Schmitz K" first="Kathryn H." last="Schmitz">Kathryn H. Schmitz</name><name sortKey="Wadden, Thomas" sort="Wadden, Thomas" uniqKey="Wadden T" first="Thomas" last="Wadden">Thomas Wadden</name><name sortKey="Wolfe, Bruce" sort="Wolfe, Bruce" uniqKey="Wolfe B" first="Bruce" last="Wolfe">Bruce Wolfe</name></country><country name="Canada"><noRegion><name sortKey="Courneya, Kerry S" sort="Courneya, Kerry S" uniqKey="Courneya K" first="Kerry S." last="Courneya">Kerry S. Courneya</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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